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Química Nova

Print version ISSN 0100-4042On-line version ISSN 1678-7064

Abstract

FILIPPIN, Fabíola Branco; SOUZA, Liliete Canes  and  MARANHAO, Raul Cavalcante. Amphotericin B associated with triglyceride-rich nanoemulsion: stability studies and in vitro antifungal activity. Quím. Nova [online]. 2008, vol.31, n.3, pp.591-594. ISSN 0100-4042.  https://doi.org/10.1590/S0100-40422008000300024.

Amphotericin B (AB) is the standard drug for invasive fungal infection therapy. It has a broad spectrum of activity and it is the best antifungal available against most yeasts and molds. Its therapeutic use, however, is limited by significant side effects, leading to a low therapeutic index when it is used as the traditional formulation (Fungizone®). Due to self-association, AB can form pores in cholesterol-containing membranes. We propose a triglyceride-rich nanoemulsion as a delivery system for AB in low levels of aggregation to reduce the toxicity against host cells.

Keywords : amphotericin B; lipid nanoemulsion; delivery system.

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