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Química Nova

Print version ISSN 0100-4042On-line version ISSN 1678-7064


OLIVEIRA, Anderson Rodrigo Moraes de; MAGALHAES, Igor Rafael dos Santos; SANTANA, Fernando José Malagueño de  and  BONATO, Pierina Sueli. Liquid-phase microextraction (LPME): fundamentals and applications to the analysis of drugs in biological samples. Quím. Nova [online]. 2008, vol.31, n.3, pp.637-644. ISSN 0100-4042.

The analysis of drugs and metabolites in biological fluids usually requires extraction procedures to achieve sample clean-up and analyte preconcentration. Commonly, extraction procedures are performed using liquid-liquid extraction or solid-phase extraction. Nevertheless, these extraction techniques are considered to be time-consuming and require a large amount of organic solvents. On this basis, microextraction techniques have been developed. Among them, liquid-phase microextraction has been standing out. This review describes the liquid-phase microextraction technique based on hollow fibers as a novel and promising alternative in sample preparation prior to chromatographic or electrophoretic analysis. The basic concepts related to this technique and its applicability in extraction of drugs are discussed.

Keywords : liquid-phase microextraction; drug analysis; biological samples.

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