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Química Nova

Print version ISSN 0100-4042On-line version ISSN 1678-7064


SANTOS, Anderson Rouge dos; KAISER, Carlos Roland  and  FEREZOU, Jean-Pierre. Ring-closing olefin metathesis: a powerful tool for the synthesis of natural macrocycles. Quím. Nova [online]. 2008, vol.31, n.3, pp.655-668. ISSN 0100-4042.

For a quarter of a century, metathesis has become indispensable for the synthesis of natural and non-natural products, particularly of biologically active compounds. This review illustrates through a maximum of appropriate examples the power and the versatility of the metathesis ring-closure (RCM) reaction as a key ring-closure methodology for the synthesis of natural macrocycles. Its high functional group compatibility as well as the possibility of further transformations makes this reaction a powerful tool in the cases where the structural framework and function requirements are difficult to meet.

Keywords : macrocycles; olefins; ring-closing metathesis.

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