Resumen

POLO, Ellen Christine; SILVA-FILHO, Luiz Carlos da; SILVA, Gil Valdo José da  y  CONSTANTINO, Mauricio Gomes. Synthesis of 1-indanones through the intramolecular Friedel-Crafts acylation reaction using NbCl₅ as Lewis acid. Quím. Nova [online]. 2008, vol.31, n.4, pp. 763-766. ISSN 0100-4042.  http://dx.doi.org/10.1590/S0100-40422008000400010.

The intramolecular Friedel-Crafts acylation reaction of 3-arylpropanoic acids to give 1-indanones can be effected in good yields under mild conditions (room temperature) by using niobium pentachloride. Our results indicate that NbCl₅ acts both as reagent (to transform carboxylic acids into acyl chlorides) and as catalyst in the Friedel-Crafts cyclization.

Palabras llave : intramolecular Friedel-Crafts acylation reaction; niobium pentachloride; synthesis of 1-indanones.