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Química Nova

versión On-line ISSN 1678-7064

Resumen

POLO, Ellen Christine; SILVA-FILHO, Luiz Carlos da; SILVA, Gil Valdo José da  y  CONSTANTINO, Mauricio Gomes. Synthesis of 1-indanones through the intramolecular Friedel-Crafts acylation reaction using NbCl5 as Lewis acid. Quím. Nova [online]. 2008, vol.31, n.4, pp. 763-766. ISSN 1678-7064.  http://dx.doi.org/10.1590/S0100-40422008000400010.

The intramolecular Friedel-Crafts acylation reaction of 3-arylpropanoic acids to give 1-indanones can be effected in good yields under mild conditions (room temperature) by using niobium pentachloride. Our results indicate that NbCl5 acts both as reagent (to transform carboxylic acids into acyl chlorides) and as catalyst in the Friedel-Crafts cyclization.

Palabras clave : intramolecular Friedel-Crafts acylation reaction; niobium pentachloride; synthesis of 1-indanones.

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