Abstract

MOREIRA, Tailane Sant'Anna et al. Extraction and purification of selectives ciclooxigenase-2 nonsteroidal antiinflammatory drugs. Quím. Nova [online]. 2009, vol.32, n.5, pp. 1324-1328. ISSN 0100-4042.  http://dx.doi.org/10.1590/S0100-40422009000500040.

Celecoxib (CB) and lumiracoxib (LM) are potent COX-2 inhibitors widely marketed for the treatment of rheumatoid arthritis and osteoarthritis. Nevertheless, it is difficult to obtain because it are protected under patents. The aim of this work was to develop an extraction method of drugs, CB and LM, in order to obtain the drug with a purity degree appropriated for use in research projects. The developed method showed to be effective of both drugs, becoming interesting due to its low cost, easy and speed of execution, application to different dosage forms (capsules and tablets) and drugs with different physicochemical properties.

Keywords : celecoxib; lumiracoxib; extraction.