Abstract

SARTORI, Elen Romão; SUAREZ, Willian Toito  and  FATIBELLO-FILHO, Orlando. Conductometric determination of metformin hydrochloride in pharmaceutical formulations using silver nitrate as titrant. Quím. Nova [online]. 2009, vol.32, n.7, pp. 1947-1950. ISSN 0100-4042.  http://dx.doi.org/10.1590/S0100-40422009000700043.

A simple, precise, rapid and low-cost conductometric titration method for the determination of metformin hydrochloride (MET) in pharmaceuticals using silver nitrate as titrant is proposed. The method was based on the chemical reaction between the chloride of metformin hydrochloride molecule and Ag(I) ions, yielding the precipitate AgCl_(s). The method was applied for MET determination in three pharmaceuticals and the obtained results with proposed method were in close agreement with those results obtained using an official method of the British Pharmacopoeia, at a 95% confidence level.

Keywords : conductometry titration; metformin hydrochloride; silver nitrate.