SciELO - Scientific Electronic Library Online

 
vol.32 issue7Application of a thiazolylazo dye as an acid-base indicator and determination of its acid ionization constantsQuantitative determination of acetaminophen, phenylephrine and carbinoxamine in tablets by high-performance liquid chromatography author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Journal

Article

Indicators

Related links

  • On index processCited by Google
  • Have no similar articlesSimilars in SciELO
  • On index processSimilars in Google

Share


Química Nova

Print version ISSN 0100-4042On-line version ISSN 1678-7064

Abstract

SARTORI, Elen Romão; SUAREZ, Willian Toito  and  FATIBELLO-FILHO, Orlando. Conductometric determination of metformin hydrochloride in pharmaceutical formulations using silver nitrate as titrant. Quím. Nova [online]. 2009, vol.32, n.7, pp.1947-1950. ISSN 0100-4042.  http://dx.doi.org/10.1590/S0100-40422009000700043.

A simple, precise, rapid and low-cost conductometric titration method for the determination of metformin hydrochloride (MET) in pharmaceuticals using silver nitrate as titrant is proposed. The method was based on the chemical reaction between the chloride of metformin hydrochloride molecule and Ag(I) ions, yielding the precipitate AgCl(s). The method was applied for MET determination in three pharmaceuticals and the obtained results with proposed method were in close agreement with those results obtained using an official method of the British Pharmacopoeia, at a 95% confidence level.

Keywords : conductometry titration; metformin hydrochloride; silver nitrate.

        · text in Portuguese     · Portuguese ( pdf epdf )

 

Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License