On-line version ISSN 1678-7064
SARTORI, Elen Romão; SUAREZ, Willian Toito and FATIBELLO-FILHO, Orlando. Conductometric determination of metformin hydrochloride in pharmaceutical formulations using silver nitrate as titrant. Quím. Nova [online]. 2009, vol.32, n.7, pp. 1947-1950. ISSN 1678-7064. http://dx.doi.org/10.1590/S0100-40422009000700043.
A simple, precise, rapid and low-cost conductometric titration method for the determination of metformin hydrochloride (MET) in pharmaceuticals using silver nitrate as titrant is proposed. The method was based on the chemical reaction between the chloride of metformin hydrochloride molecule and Ag(I) ions, yielding the precipitate AgCl(s). The method was applied for MET determination in three pharmaceuticals and the obtained results with proposed method were in close agreement with those results obtained using an official method of the British Pharmacopoeia, at a 95% confidence level.
Keywords : conductometry titration; metformin hydrochloride; silver nitrate.