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Química Nova

versión impresa ISSN 0100-4042versión On-line ISSN 1678-7064


SANTOS, Érica L. et al. Toxicity and antioxidant activity of flavonoids from Lonchocarpus filipes root bark. Quím. Nova [online]. 2009, vol.32, n.9, pp.2255-2258. ISSN 0100-4042.

The phytochemical investigation of dichloromethane extract from root bark of Lonchocarpus filipes Benth (Leguminosae) afforded four flavonoids including three dibenzoylmethane derivatives rarely found in nature. The structures were established based on their spectral data (1H and 13C NMR, 2D-NMR) as being: lanceolatin B (1), pongamol (2), (E)-7-O-methylpongamol (3) and (E)-9-O-methylpongamol (4). Compound (4) is described herein for the first time as a natural product. The extracts and the isolated compounds (1), (2) and (3) displayed high toxicity in the brine shrimp lethality assay. Only compound (2) showed antioxidant activity using a DPPH radical scavenging assay. This is the first report on the phytochemical study of Lonchocarpus filipes.

Palabras clave : Lonchocarpus filipes; flavonoids; dibenzoylmethanes.

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