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Química Nova

Print version ISSN 0100-4042On-line version ISSN 1678-7064

Abstract

BAJERSKI, Lisiane et al. Determination of cetirizine in tablets and compounded capsules: comparative study between CE and HPLC. Quím. Nova [online]. 2010, vol.33, n.1, pp.114-118. ISSN 0100-4042.  https://doi.org/10.1590/S0100-40422010000100021.

A capillary electrophoresis (CE) method was developed and validated for determination of cetirizine dihydrochloride in tablets and compounded capsules. The electrophoretic separation was performed in an uncoated fused-silica capillary (40 cm x 50 μm i.d.) using 20 mmol L-1 sodium tetraborate buffer (pH 9.3) as background electrolyte, a hydrodinamic sample injection at 50 mBar for 5 s, 20 KV applied voltage at 25 °C, and detection at 232 nm. The proposed method was compared with the high performance liquid chromatographic (HPLC) method previously validated for this drug, and statistical analysis showed no significant difference between the techniques.

Keywords : cetirizine; capillary eletrophoresis; high performance liquid chromatography.

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