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Química Nova

versión impresa ISSN 0100-4042

Resumen

REGO, Jardes Figuerêdo do; MOURA, Jacira Izidório de  y  MOITA, Graziella Ciaramella. Spectrophotometric olanzapine determination in pharmaceutical formulations: method development and validation. Quím. Nova [online]. 2010, vol.33, n.2, pp. 471-477. ISSN 0100-4042.  http://dx.doi.org/10.1590/S0100-40422010000200041.

Spectrophotometric methods of zero order, first and second derived order had been developed for olanzapine determination in tablets using ethanol and isopropanol as solvent. The two solvents revealed to be adequate. For the three methods the calibration curve coefficient of correlation had been greater than 0.9998 with limit of detection varying from 0.068 to 0.190 mg L-1, in ethanol, and 0.026 to 0.205 mg L-1, in isopropanol. The inter-day precision was inferior to 1.1 and 1.9 mg L-1 for ethanol and isopropanol, respectively. The average recoveries varied from 98 to 101%, in ethanol and 99 to 103% in isopropanol.

Palabras llave : olanzapine; UV spectrophotometry; validation.

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