Resumo

TESTA, Gláucio et al. Chemical constituents of the leaves and anti-inflammatory activity evaluation of extracts of roots and leaves of Guettarda pohliana Müll. Arg. (Rubiaceae). Quím. Nova [online]. 2012, vol.35, n.3, pp. 527-529. ISSN 0100-4042.  http://dx.doi.org/10.1590/S0100-40422012000300016.

This phytochemical investigation of Guettarda pohliana leaves led to the isolation of the triterpenes pomolic acid, rotundic acid, 3β,6α,19α,23-tetrahydroxyurs-12-en-28-oic acid, clethric acid, ursolic acid and oleanolic acid, the monoterpenoids loliolide and secoxyloganin, besides daucosterol and steroids. The structures of the isolated compounds were assigned on the basis of NMR data, including two-dimensional NMR methods. The anti-inflammatory activity of the crude methanolic extracts from leaves and roots, as well as of their fractions, was evaluated.

Palavras-chave : Guettarda pohliana; triterpenoid; anti-inflammatory activity.