versão impressa ISSN 0100-4042
QIN, Minmin et al. Photochemical characteristics of diclofenac and its photodegradation of inclusion complexes with β-cyclodextrins. Quím. Nova [online]. 2012, vol.35, n.3, pp. 559-562. ISSN 0100-4042. http://dx.doi.org/10.1590/S0100-40422012000300022.
Diclofenac is one of most frequently detected compounds in the water cycle. In this work, the effect of initial concentration, liquid inclusion complexes with β-Cyclodextrins (β-CDs) on the photodegradation of diclofenac were studied. Six phototransformation products were detected by HPLC chromatograms. UV-absorption spectra of diclofenac and phototransformation products were determined. One of the phototransformation products was identified. The degradation followed pseudo-first-order kinetics. The experiment showed that irradiation of diclofenac in the presence of β-CDs increase photodegradation rate and determined the optimal molar ratio of diclofenac to β-CDs as 1:2. The reduced photohaemolytic activity of diclofenac in the presence of β-CDs may be attributed to the sequestering and stabilizing of the radical intermediates and /or photoproducts by complexation.
Palavras-chave : diclofenac; β-cyclodextrins; photodegradation.