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Química Nova

Print version ISSN 0100-4042

Abstract

VASCONCELOS, Jackson Nunes e et al. Rotenoids from Tephrosia toxicaria with larvicidal activity against Aedes aegypti, the main vector of dengue fever. Quím. Nova [online]. 2012, vol.35, n.6, pp.1097-1100. ISSN 0100-4042.  https://doi.org/10.1590/S0100-40422012000600005.

In the search for new larvicides from plants, we have investigated the potential activity of the rotenoids deguelin (1), 12a-hydroxy-α-toxicarol (2) and tephrosin (3), isolated from the bioactive ethanol extract of roots of Tephrosia toxicaria Pers., against Aedes aegypti, the main vector of dengue. The absolute configuration of these compounds was determined by circular dichroism (CD) spectra. The LC50 values of the compounds evaluated justify the potential of T. toxicaria as a new natural larvicide.

Keywords : Tephrosia toxicaria; rotenoids; Aedes aegypti.

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