Abstract

CACHIBA, Thomas Haruo et al. Synthesis and preliminary evaluation of N-acylhydrazone compounds as antibacterial and antifungal agents. Quím. Nova [online]. 2012, vol.35, n.8, pp. 1566-1569. ISSN 0100-4042.  http://dx.doi.org/10.1590/S0100-40422012000800014.

We describe the synthesis and evaluation of N-acylhydrazone compounds bearing different electron-donating groups in one of its aromatic rings, obtained using a four-step synthetic route. IC₅₀ values against pathogenic fungi and bacteria were determined by serial microdilution. Compounds showed low activity against Staphylococcus aureus, Escherichia coli and Pseudomonas aeruginosa. By contrast, a derivative with a meta-oriented electron-donating group showed significant activity (IC50) against Candida albicans (17 µM), C. krusei (34 µM) and C. tropicalis (17 µM). Results suggest this is a promising lead-compound for synthesis of potent antifungal agents.

Keywords : N-acylhydrazones; antibacterial activity; antifungal activity.