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Química Nova

Print version ISSN 0100-4042


SILVA, Dayanne Meneses et al. Ent-kaurane diterpenoids and other constituents from the stem of Xylopia laevigata (Annonaceae). Quím. Nova [online]. 2012, vol.35, n.8, pp.1570-1576. ISSN 0100-4042.

Phytochemical investigation of the hexane extract from the stem of Xylopia laevigata led to the isolation of the ent-kaurane diterpenoids, ent-kaur-16-en-19-oic acid, 4-epi-kaurenic acid, ent-16β-hydroxy-17-acetoxy-kauran-19-al, ent-3β-hydroxy-kaur-16-en-19-oic acid, and ent-16β,17-dihydroxy-kauran-19-oic acid, as well as spathulenol and a mixture of β-sitosterol, stigmasterol and campesterol. The identification of the compounds was performed on the basis of spectrometric methods including GC-MS, IR, and 1D and 2D NMR. Potent larvicidal activity against Aedes aegypti larvae with LC50 of 62.7 µg mL-1 was found for ent-3β-hydroxy-kaur-16-en-19-oic acid. This compound also showed significant antifungal activity against Candida glabrata and Candida dubliniensis with MIC values of 62.5 µg mL-1.

Keywords : Xylopia laevigata; ent-kaurane-diterpenes; larvicidal and antifungal properties.

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