Abstract

FRANQUI, Lidiane Silva; VIEIRA, André Coutinho; MAIA, Patrícia Penido  and  FIGUEIREDO, Eduardo Costa. Molecularly imprinted solid-phase extraction of urinary trans-trans muconic acid and analysis by gas chromatography-mass spectrometry. Quím. Nova [online]. 2012, vol.35, n.8, pp. 1577-1581. ISSN 0100-4042.  http://dx.doi.org/10.1590/S0100-40422012000800016.

This paper describes selective molecularly imprinted solid-phase extraction of ttMA from urine samples followed by derivatization and analysis by gas chromatography/mass spectrometry (GC/MS). The analytical calibration curve ranged from 0.3 to 7.0 mg L^-1 (r = 0.999) and the limit of quantitation (LOQ) was 0.3 mg L^-1. The method was applied for the determination of ttMA in urine samples from smokers and concentrations detected ranged from < LOQ to 1.64 mg L^-1. Thus, the proposed method proved adequate for the determination of urinary ttMA in the biomonitoring of occupational exposure to low levels of benzene.

Keywords : trans, trans-muconic acid; molecularly imprinted polymers; gas chromatography [mass spectrometry].