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Química Nova

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MARQUES, Marcelo Volpatto; BISOL, Tula Beck  and  SA, Marcus Mandolesi. Biginelli and Mannich multicomponent reactions in the undergraduate organic chemistry laboratory: a didactic approach to green chemistry principles. Quím. Nova [online]. 2012, vol.35, n.8, pp.1696-1699. ISSN 0100-4042.

The introduction of Mannich and Biginelli multicomponent reactions in a practical Organic Chemistry course is presented in this article. Procedures described in the literature were adapted for use under the simple conditions available in undergraduate laboratories and were selected on the basis of Green Chemistry principles and practicality of synthesis. The reactions are easy to carry out and all products are readily isolated as crystalline solids with yields ranging from moderate to high.

Keywords : Mannich reaction; Biginelli reaction; Green Chemistry.

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