SciELO - Scientific Electronic Library Online

 
vol.37 issue3Glycolysis of poly(3-hydroxybutyrate) via enzyme catalysisEvaluation of antiradical assays used in determining the antioxidant capacity of pure compounds and plant extracts author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Journal

Article

Indicators

Related links

Share


Química Nova

Print version ISSN 0100-4042

Abstract

GOMES, Patrícia Ramos et al. Synthesis and evaluation of antimalarial activity of curcumin derivatives. Quím. Nova [online]. 2014, vol.37, n.3, pp.492-496. ISSN 0100-4042.  http://dx.doi.org/10.5935/0100-4042.20140075.

One of the main challenges in the development of new antimalarial drugs is to achieve a viable lead candidate with good pharmacokinetic properties. Curcumin has a broad range of biological activities, including antimalarial activity. Herein, we report the antimalarial activity of six curcumin derivatives (6-12) and an initial analysis of their pharmacokinetic properties. Five compounds have demonstrated potent activity against the P. falciparum in vitro (IC50 values ranging from 1.7 to 15.2 µg mL-1), with moderate or low cytotoxicity against the HeLa cell line. The substitution of the carbonyl group in 6 by a 2,4-dinitrophenylhydrazone group (to afford 11) increases the Selective Index. These preliminary results indicate curcumin derivatives as potential antimalarial compounds.

Keywords : curcumin derivatives; antimalarial chemotherapy; Plasmodium falciparum.

        · text in Portuguese     · Portuguese ( pdf )

 

Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License