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SÍNTESE DE N-GLICOSILSULFONAMIDAS DERIVADAS DE D-GLICOSE E N-ACETILGLICOSAMINA

SYNTHESIS OF D-GLUCOSE- AND N-ACETYLGLUCOSAMINE-BASED N-GLYCOSYLSULFONAMIDES

Herein, we report the synthesis of β-N-glycosylsulfonamides derivatives of D-glucose and N-acetylglucosamine using conventional methods. We also describe a procedure that allows the preparation of these compounds in good yields without the anomerization of the intermediate glycosylamines. This method includes the intermediates obtained from the less reactive 1- and 2-naphthalenesulfonyl chlorides.

N-glycosylsulfonamides; D-glucose and N-acetylglucosamine; new procedure


Sociedade Brasileira de Química Instituto de Química, Universidade Estadual de Campinas (Unicamp), CP6154, 13083-0970 - Campinas - SP - Brazil
E-mail: quimicanova@sbq.org.br