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Eclética Química

Print version ISSN 0100-4670

Abstract

SOUSA, R. A. de; SEMAAN, F. S.; BAIO, J. A. F.  and  CAVALHEIRO, E. T. G.. Fast determination of minoxidil by photometric flow titration. Eclet. Quím. [online]. 2005, vol.30, n.3, pp. 79-84. ISSN 0100-4670.  http://dx.doi.org/10.1590/S0100-46702005000300010.

A photometric flow titration based on the redox reaction between KMnO4 and minoxidil is described. The best titration results were observed at 3.20 x 10-4 mol L-1 KMnO4 and 1.00 x 10-3 mol L-1 minoxidil, using the minoxidil solutions as titrant. The flow rate was fixed at 17 mL min-1 and the titrant was added to the system in aliquots of 500 µL, the color changes were monitored at 550 nm. The method was applied to commercial samples and compared with the results from a chromatographic procedure. Recoveries from 97.6 to 102.8 % were observed depending on the sample. Comparison with the chromatographic procedure reveled relative errors of 3.5 - 4.0 %.

Keywords : minoxidil determination; photometric titration; flow titration.

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