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Eclética Química

versão impressa ISSN 0100-4670versão On-line ISSN 1678-4618

Resumo

BARICCATTI, R. A. et al. Hydrolytic and photochemistry degradation of the amoxicillin in β-cyclodextrin. Eclet. Quím. [online]. 2008, vol.33, n.4, pp.79-84. ISSN 1678-4618.  https://doi.org/10.1590/S0100-46702008000400010.

This work has like purpose monitors the degradation of the drug amoxicillin in the presence and absence of β-cyclodextrin, through techniques spectroscopy. For this, there was accompanied the hydrolysis of the drug protected of the light for around 400 hours. The results indicate that, initially, the cyclodextrin does not alter the hydrolysis of the amoxicillin, however, after 250 hours there is an increase of the hydrolysis of the amoxicillin when present at cyclodextrin. Another variable was the irradiation of the sample with radiation in the region of the UV, we see that the solutions containing β-cyclodextrin suffer a slower phototransformation (26,8%) than the solutions without β-cyclodextrin, when irradiated by UV radiation.

Palavras-chave : Amoxicillin; β-cyclodextrin; photodegradation.

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