Revista do Colégio Brasileiro de Cirurgiões
Print version ISSN 0100-6991
FRUCTUOSO, Paulo Cesar; MAIA, Accyoli Moreira and ACCETTA, Italo. The surgeon facing new therapies for cancer treatment. Rev. Col. Bras. Cir. [online]. 2001, vol.28, n.5, pp. 370-374. ISSN 0100-6991. http://dx.doi.org/10.1590/S0100-69912001000500010.
The cancer treatement has been subjected to substantial changes, mainly concerning clinical specialities. The advances on tumours study, especially related to genetics and molecular biology, greatly increased our understanding about many aspects of carcinogenesis, neoplasic growth and metastasizing process, untill now obscure. In this context, surgery seems to be attained its limits in trying to erradicate completely the disease, and although the great resections made, this aim has not been succeeded in many cases. New treatments are emerging each year and between the most promising we can highlight tumour angiogenesis chemical blocking agents, with highly promising experimental results. At the same time of the beginning of clinical researchs about these drugs, the authors present a review work, with the objective of presenting a general survey of the knowledge achieved about these recently discovered drugs in tumours control.
Keywords : Angiogenesis; Tumour angiogenesis blockers; Angiostatin; Endostatin.