SciELO - Scientific Electronic Library Online

vol.29 issue6Advantages of internal jugular vein preservation in unilateral neck dissectionsThe use of human squamous mucosa culture in the treatment of extensive buccal premalignant lesions author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




Related links


Revista do Colégio Brasileiro de Cirurgiões

Print version ISSN 0100-6991On-line version ISSN 1809-4546


MEDEIROS, Aldo da Cunha et al. Effect of factor XIII on the healing of rat skin in use of corticosteroid. Rev. Col. Bras. Cir. [online]. 2002, vol.29, n.6, pp.324-329. ISSN 0100-6991.

OBJETIVE: There is increasing evidence that coagulation factor XIII is protective in models of wound healing . Our purpose is to observe the effects of coagulation factor XIII on the healing of skin wound of rats treated with corticosteroid. METHOD: Fourty Wistar rats, weighing 245±15g, were randomly divided into four groups. In group A (n=10) the rats received corticosteroid IM. In group B (n=10) corticosteroid and factor XIII were used IM. In group C ( n=10) the rats received only factor XIII and in group D (n=10) saline solution was used (control). The tensil strenght of the wound was measured by a computed tensiometer and the hystopatologic evolution of healing was quantitated by a digital system. RESULTS: The results indicated a significant difference (p<0.0001) of tensil strenght between group A ((523.6gf) and the control (D) group (1480.4gf). In group B the tensil strenght (868.8gf) was significantly greater than in group A (p<0.0001). The factor XIII didn't increase the tensil strenght in group C, when compared with control (p=0,067). The hystopatologic analysis indicated a similar tendency observed in tensil strenght. CONCLUSIONS: There was a strong correlation between factor XIII, tensil strenght and healing of sutured skin wounds of rats treated with corticosteroid. The fator XIII didn't change the wound healing in rats with no corticosteroid.

Keywords : Factor XIII; Healing; Skin; Corticosteroid; Tensil strenght; Hystopatology.

        · abstract in Portuguese     · text in Portuguese     · Portuguese ( pdf )


Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License