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Revista do Colégio Brasileiro de Cirurgiões

Print version ISSN 0100-6991On-line version ISSN 1809-4546


FONTES, Carlos Edmundo Rodrigues et al. Study of repair of rat's colon wound whith serosal of jejunal wall using cyanoacrylate and fibrin glue. Rev. Col. Bras. Cir. [online]. 2006, vol.33, n.2, pp.68-73. ISSN 0100-6991.

BACKGROUND: The present experiment aimed to compare the effect of the use of cyanoacrylate and fibrine glue as adesive on repared colon's wounds with the serosal side of jejuno's wall. METHODS: Forty five male, young adult Wister rats, weighting about 260 g , from the University of Maringá were used.After having been deeply anaesthetized (thiopental was used), the animals underwent a surgery, and a pattern 0,5 cm wound was made, 2 cm away from the cecum, in the caudal location. Group one the wound was repaired by using the jejunal serosal wall and suture.On group two the jejunal serosal wall and fibrine glue was used. Finally on group three the repair was made by using the jejunal serosal wall and cyanoacrylate. The animals were submited to roentgenogram with barium enema on the fourth postoperative day to search for stenosis. On the seventh day, after having been anaesthetized, animals were submited to a laparotomy, segments were collected for both macroscopic and microscopic study. RESULTS: Fibrine glue has shown better result on repair, due to the production of collagen fibres. CONCLUSION: The experiment has come to prove that the wound made on rat's colon can be repaired by the jejunal serosal wall joined to the wound either using the fibrine glue or cyanoacrylate.

Keywords : Transplantation; autologous; Intestines; Wounds and injuries; Colon; Adhesives; Fibrin tissue adhesive.

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