Revista do Colégio Brasileiro de Cirurgiões
versão impressa ISSN 0100-6991
NASSIF, Aissar Eduardo et al. Epidemiologic profile and prognostic factors in clinically localized prostate adenocarcinoma submitted to surgical treatment. Rev. Col. Bras. Cir. [online]. 2009, vol.36, n.4, pp. 327-331. ISSN 0100-6991. http://dx.doi.org/10.1590/S0100-69912009000400010.
OBJECTIVE: Radical prostatectomy remains the standard treatment for early prostate cancer. This study was conducted to evaluate the outcome and prognostic factors of radical prostatectomy. METHODS: A total of 500 patients with prostate cancer underwent radical prostatectomy at Santa Rita hospital- Maringa-PR, between 2000 and 2006. Clinical staging, preoperative prostate-specific antigen (PSA) and Gleason score were evaluated with pathological stage and margin status. Follow-up PSA monitoring and survival were analyzed. RESULTS: Of 500 patients with clinical localized disease with a median follow up of 36,7±18,8 months. The average operative duration was 190± 45 minutes and the average intra-operative bleeding was 630 ml. The patients' preoperative serum PSA was 7,8 ± 4,5 ng/dl , with a higher proportion of Gleason Score < 6(72%) and The TNM stage pT2c (65%). For late postoperative complications: incontinence in 2% and 46 % with erectile dysfunction. CONCLUSION: Radical prostatectomy in men shows excellent results. The chance of recurrence was directly associated with PSA = 10 ng/ml, high Gleason score and inversely proportional to age.
Palavras-chave : Prostatic neoplasms; Prostatic neoplasms [surgery]; Prognosis; Adenocarcinoma [epidemiology]; Prostatectomy.