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Revista do Colégio Brasileiro de Cirurgiões
Print version ISSN 0100-6991
COELHO, Julice Medeiros et al. Effects of silver sulfadiazine, ipê roxo (tabebuia avellanedae) extract and barbatimão (stryphnodendron adstringens) extract on cutaneous wound healing in rats. Rev. Col. Bras. Cir. [online]. 2010, vol.37, n.1, pp. 045-051. ISSN 0100-6991. http://dx.doi.org/10.1590/S0100-69912010000100010.
OBJECTIVE: Morphological study of effects of silver sulfadiazine, Tabebuia avellanedae (ipê-roxo) extract and Stryphnodendron adstringens (barbatimão) extract on cutaneous wound healing was done. METHODS: Ninety six Wistar rats were used. All animals underwent a femoral right vein ligation to induce a venous hypertension. Thirty days after the cutaneous wound was done, they were divided into groups of four animals. Group S received silver sulfadiazine topical application; group IR, Tabebuia avellanedae extract topical application; group B received Stryphnodendron adstringens extract topical application and group C received physiological solution topical application, every day for a period of seven, 14 and 30 days. Histology analyzed the presence vascular proliferation, neutrophil and lymphocite, fibroblast, collagen fiber and epithelization. RESULTS: The macroscopic analysis showed complete epithelization at 14 days in group S, IR e B. The histological data at 14 days of observation only group C still showed incomplete epithelization in six animals. At the same period there was a statistic significant difference between the control group and the others groups as inflammation process and neovascularization. About the presence fibroblasts and collagen, there was statistic significant difference between the control group and the others groups at the 30 days because at this period the control group still showed fibroblasts and collagen lower when compared to the others groups. CONCLUSION: The morphological analysis of the results permits to infer that the group S, IR and B had a better healing of skin wounds, when compared with the control.
Keywords : Stryphnodendron adstringens; Healing wound; Tabeluia avellanedae; Silver sulfadiazadine.