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Revista do Colégio Brasileiro de Cirurgiões
Print version ISSN 0100-6991
TRINDADE, Lilian Cristine Teixeira et al. Evaluation of topical metronidazole in the healing wounds process: an experimental study. Rev. Col. Bras. Cir. [online]. 2010, vol.37, n.5, pp. 358-363. ISSN 0100-6991. http://dx.doi.org/10.1590/S0100-69912010000500009.
OBJECTIVE: To assess the efficacy of topical a 4% metronidazole solution in wounds healing by secondary intention in rats. METHODS: We made circular wounds two inches in diameter at the back of rats and studied healing at 3, 7, 14 and 21 days. The wound contraction and epithelialization were assessed by peripheral digital planimetry and myofibroblasts by immunohistochemistry with a-SMA. RESULTS: There was no difference between groups regarding wound contraction. In wounds treated with metronidazole peripheral epithelialization was evident early on day 3 (p <0.001) and there were no differences in other periods. In the control group, the number of myofibroblasts was higher on day 7 (p = 0.003) and day 14 (p = 0.001) and in the experimental group it was suggestively higher on day 3 (p = 0.06). CONCLUSION: Metronidazole 4% solution at a dose of 50 mg/kg applied topically to wounds healing by secondary intention facilitates early peripheral epithelialization, does not interfere with wound contraction and delays the appearance of myofibroblasts.
Keywords : metronidazole; Wound healing; Fibroblasts; Rats.