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Revista do Colégio Brasileiro de Cirurgiões

Print version ISSN 0100-6991

Abstract

SILVA, Evandro de Moraes e et al. Biochemical study of dermatan sulfate glycosaminoglycan in adult male patients with Nyhus type II inguinal hernia. Rev. Col. Bras. Cir. [online]. 2011, vol.38, n.3, pp. 167-171. ISSN 0100-6991.  http://dx.doi.org/10.1590/S0100-69912011000300005.

OBJECTIVE: To compare the amount of the dermatan sulfate glycosaminoglycan between male patients with Nyhus type II inguinal hernias and subjects without inguinal hernia, aged between 20 and 40 years. METHODS: Two groups were formed: One with 15 male patients with Nyhus type II inguinal hernia and aged between 20 and 40 years with ASA risk I and II, and a control group of ten individuals, also males between 20 and 40, who had died up to 24 h before. We excluded female patients, diabetic patients with connective tissue disease, smokers and surgical risk ASA III and IV. We resected a sample of 1 cm2 of the transversalis fascia in the middle of the inguinal trigone, and 1 cm2 of the anterior sheath of the rectus abdominis muscle in the groin for the quantification of dermatan sulfate glycosaminoglycans by densitometry after agarose gel electrophoresis. RESULTS: The amount of dermatan sulfate showed no statistically significant difference between patients with inguinal hernia and individuals without inguinal hernia in both the transverse fascia (p = 0.108) and anterior sheath of the rectus abdominis muscle (p = 0.292). CONCLUSION: There was no difference in the amount of the dermatan sulfate glycosaminoglycan among patients with Nyhus type II inguinal hernias and subjects without inguinal hernia in adult males.

Keywords : Glycosaminoglycan; Dermatan sulfate; Extracellular matrix; Hérnia, inguinal.

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