SciELO - Scientific Electronic Library Online

 
vol.39 issue6Predictive factors of morbidity in distal pancreatic resectionsAnalysis of adhesions resulted from mesh fixation with fibrin sealant and suture: experimental intraperitoneal model author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Journal

Article

Indicators

Related links

Share


Revista do Colégio Brasileiro de Cirurgiões

Print version ISSN 0100-6991

Abstract

VASCONCELLOS, Leonardo de Souza; ALBERTI, Luiz Ronaldo; ROMEIRO, Juliana Ribeiro  and  PETROIANU, Andy. Influence of cholestatic jaundice on the weight variance in an experimental model. Rev. Col. Bras. Cir. [online]. 2012, vol.39, n.6, pp.502-508. ISSN 0100-6991.  https://doi.org/10.1590/S0100-69912012000600010.

OBJECTIVE: To evaluate the influence of cholestatic jaundice in weight variation. METHODS: We used 64 adult rats divided into six groups: F1 (n = 6): normal females; F2 (n = 6): laparotomy females; F3 (n = 20): jaundiced females; M1 (n = 6): normal males; M2 (n = 6): laparotomy males; M3 (n = 20): jaundiced males. Jaundice was obtained by ligation and section of the biliopancreatic duct. The animal weights were recorded weekly for seven weeks. On the 14th day of the experiment, bilirubin and gonadal hormones were assessed. After the seventh week a histological study of the liver was performed. RESULTS: The animals in groups F3 and M3 showed elevated bilirubin and decreased body mass when compared to the other groups. The weight differences were significant from the fourth week on amongst females and from the fifth in males. In Jaundiced animals there was increased estradiol and decreased progesterone and testosterone. Perivenular septa and periportal fibrosis, cholangitis and bile duct hyperplasia occurred in the liver of jaundiced rats. No animal showed cirrhosis. CONCLUSION: There was decrease in murine body weight in the presence of cholestatic jaundice in both genders.

Keywords : Cholestasis; Jaundice; Hyperbilirubinemia; Gonadal hormones; Mice body weight.

        · abstract in Portuguese     · text in English | Portuguese     · English ( pdf ) | Portuguese ( pdf )

 

Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License