Busnardo, Simões, 20108
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HeNe with power 4J/cm2 applied for 12 seconds per wound site in continuous mode, 5mW, wavelength of 632.8 nm and the laser beam area of 0.015 cm2. |
Increase of type III collagen, decreased inflammatory infiltrate and early resolution of wound inflammatory phase. |
Silva et al., 201016
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Laser applied in 15 Wistar rats divided into three groups: G1 (control), G2 (2J/cm2) and G3 (4 J/cm2), with wavelength of 670 nm and irradiated for 10 consecutive days on skin lesion. |
The dose of 4J/cm2 differed significantly from the others concerning the reepithelialization process. |
Frigo et al., 200917
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Application of laser once a day on tumor cells, for three consecutive days, with the following parameters: 632nm, 50 mW, 2mm2 pointer, irradiation area of 2.5 W/cm2 and times of 60 and 420 seconds at doses of 150J/cm2(group 1, in vitro) and 1050J/cm2 (group 2, in vivo), respectively. The third group was not irradiated (control group). |
Between the in vitro and the control group, there was no statistically significant difference in the growth of tumor cells. Comparing group 2 and control, there was significant growth of mass and volume to the tumor, as well as a large number of blood vessels in the in vivogroup. |
Felice et al., 20097
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Application of AlGaInP laser (658 nm, 4J/cm2) in a localized and scanned manner on human decubitus and venous ulcers. |
Reduction of the wounds area. |
Maiya et al., 200918
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He-Ne laser on skin wounds in diabetic rats, with a wavelength of 632.8 nm and doses of 3-9J/cm2, five days / week until complete healing. |
Increased production of granulation tissue in the animals that received doses of 4-5J/ cm2, especially on the fifth day of treatment. |
Inoe et al., 200811
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HeNe laser used in doses of 3 and 6J/cm2, 45 W of power and wavelength of 632nm and a control group, for surgical wounds of healthy rabbits. The animals were evaluated at 7, 14 and 21 days. |
Observed the presence of mature granulation tissue at 14 days and absence of hemorrhage and exudate at day 21. |
Channual et al., 20085
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Low power laser with a wavelength of 585 nm and a dose of 7J/cm2 on skin wounds of rats. |
Permanent vascular proliferation after the fifth day of application. |
Pinto et al., 20074
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First week twice with an interval of 48 hours in the weeks following 1x/week, in a localized manner and without the use of additional medication. |
The results revealed granulation tissue, reducing inflammation and pain relief from the first application. |
Castano et al., 200719
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Arthritis in rats treated for five days with 810nm, power 79 and 790mW, doses of 3 and 30J/cm2 and intensities of 5 and 50mW/cm2. |
Increase of adenosine triphosphate (ATP) and improved inflammatory process. |
Rocha Júnior et al., 200620
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Twelve animals divided into two groups: control and experimental. Wound treated for seven days with GaAs laser, pulsatile dose 3.8 J/cm2 and power of 15mW time for 15 seconds. |
Tissue repair significantly larger and more organized in the experimental group. |
Hopkins et al., 200421
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Abrasive damage induced in non-dominant upper limb in two groups of healthy people. One group was treated with a dose of 8J/cm2, wavelength 820nm and two minutes exposure. The other group was treated under the same parameters for five seconds. A third group was not treated. |
The groups treated with low level laser showed a statistically significant reduction in the wound when compared to the control group at the 6th, 8th and 10th days of treatment. |
Envemeka, 200122
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HeNe laser (632.8 nm, continuous) and GaAs laser (904nm, continuous) in cutaneous lesions of rats. |
Improvement of wound healing for both wave lengths adopted, though the latter presented more pronounced findings. |
Landau, Schattner, 200123
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HeNe laser (632nm / 5mW and 904 nm/60W; 4 J/cm2) associated with topical hyperbaric oxygen supply for 20 minutes per session on diabetic foot ulcers over 14 weeks. |
Complete healing of ulcers after 25 sessions and only 4% of recurrence. |
Al-watban, Andres, 20016
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HeNe (632.8 nm wavelength, dose of 5 J/cm2 and power of 10.53 mW/cm2), applied three times per week in in vivo cells until complete healing of the wound. |
Increased cell proliferation (fibroblasts and mitochondria), as well as microcirculation, with a consequent increase in cellular metabolism. |