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Pesquisa Veterinária Brasileira
On-line version ISSN 1678-5150
FILAPPI, Andreane R. et al. Metabolism and distribution of fluor in lambs chronically treated with sodium fluoride. Pesq. Vet. Bras. [online]. 2008, vol.28, n.2, pp. 124-128. ISSN 1678-5150. http://dx.doi.org/10.1590/S0100-736X2008000200006.
The objective of the present study was to evaluate fluorine metabolism in growing lambs. Twelve 5-month-old male lambs maintained on alfalfa hay (3% BW) and non-fluorinated water ad libitum were used. Animals were allocated into Control, receiving 5g NaCl/animal/day + 0.2mg I/kg dry matter) and Treated group, receiving the same treatment plus sodium fluoride (4.7mg F/kg body weight). Mineral treatment was given by gavage, daily for 150 days. Blood, urine and fecal samples were collected during and the end of the experiment. At the end of treatment period animals were euthanized and kidney, pineal and bone samples were collected. Urine F was higher in treated animals throughout the experiment. Bone F levels were also increased in treated animals; pineal F content however, was not different between groups. Kidney histology revealed no differences. It is concluded that chronic F administration induces accumulation of the element in the skeleton. However such fact appears not to be detrimental to animals. Rates of F accumulation in bone and urine excretion obtained in other species can not be used in growing lambs.
Keywords : Fluoride; sheep; serum; urine; bone.