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Pesquisa Veterinária Brasileira

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TOCHETTO, Camila; SOUZA, Tatiana M.; BARROS, Claudio S.L.  and  FIGHERA, Rafael A.. Epidemiological, clinical, hematological, and pathological aspects of acute erythroid leukemia (LMA M6) in cats. Pesq. Vet. Bras. [online]. 2011, vol.31, n.7, pp.610-619. ISSN 0100-736X.

The epidemiological, clinical, hematological, and pathological aspects of acute erythroid leukemia (LMA M6) were studied in 10 cats that died from this condition. The results obtained in the present study differ from those previously described in the literature regarding the following aspects: 1) The disease occurred as a bimodal model related to the age of affected cats, in which 50% were1-3-years-old and 50% were 10 years-old or above; 2) almost all affected cats (87.5%) displayed polychromasia, possible resulting from extramedullar erythropoiesis; 3) in all cases there were multiple foci of hematopoietic cells, mainly erythropoietic, in multiple organs including spleen (85.7%), lymph nodes (71.4%), liver (57.1%), and kidney (28.6%); 4) in some cases (28.6%) these foci could be observed on gross examination as metastasis, but they always histologically differ from bone marrow in regard to the proportion of erythroid precursors involved; 5) at least in one case a continuum patologicum occurred with the condition evolving to another form of LMA (LMA M4), a phenomenon coined as "lineage infidelity". This paper discuss these differences and stresses the fundamental criteria to establish a definitive diagnosis of this condition, which is the most import form of leukemia in cats from our region.

Keywords : Diseases of cats; hematology; hematopathology; acute erythroid leukemia; erythroleukemia; erythremic myelosis.

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