Fig.1.
Studies performed in the last years on hematopoietic stem cells from canine bone marrow. (Osgood et al. 1939Osgood E.E., Riddle M.C. & Mathews T.J. 1939. Aplastic anemia treated with daily transfusions and intravenous marrow: case report. Ann. Intern. Med. 13:357-367., Thomas et al. 1962Thomas E.D., Collins J.A., Hernan Jr E.C. & Ferrebee J.W. 1962. Marrow transplantations in lethally irradiated dogs given methotrexate. Blood 19:217-28., Epstein et al. 1967Epstein R.B., Bryant J. & Thomas E.D. 1967. Cytogenetic demonstration of permanent tolerance in adult outbred dogs. Transplantation 5:267-272., Escobar et al. 2012Escobar C., Grindem C., Neel J.A. & Suter S.E. 2012. Hematologic changes after total body irradiation and autologous transplantation of hematopoietic peripheral blood progenitor cells in dogs with lymphoma. Vet. Pathol. 49(2):341-343., Killian et al. 2013Killian D., Reichard M., Knueppel A., Lange S., Sekora A., Knuebel G., Murua E.H., Guthoff R., Stachs O. & Junghanss C. 2013. Distribution changes of epithelial dendritic cells in canine cornea and mucous membranes related to hematopoietic stem cell transplantation. In Vivo 27(6):761-771., Sato et al. 2013Sato M., Storb R., Loretz C., Stone D., Mielcarek M., Sale G.E., Rezvani A.R. & Graves S.S. 2013. Inducible costimulator (ICOS) up-regulation on activated T cells in chronic graft-versus-host disease after dog leukocyte antigen-nonidentical hematopoietic cell transplantation: a potential therapeutic target. Transplantation 96(1):34-41., Mathes et al. 2014Mathes D.W., Chang J., Hwang B., Graves S.S., Storer B.E., Butts-Miwongtum T., Venda G.E. & Storb R. 2014. Simultaneous transplantation of hematopoietic stem cells and a vascularized composite allograft leads to tolerance. Transplantatin 98(2):131-138., Vrecenak et al. 2014Vrecenak J.D., Pearson E.G., Santore M.T., Todorow C.A., Li H., Radu A., Bhatti T., Peranteau W.H., Johnson M.P. & Flake A.W. 2014. Stable long-term mixed chimerism achieved in a canine model of allogeneic in utero hematopoietic cell transplantation. Blood 124(12):1987-95., Rosinski et al. 2015Rosinski S.L., Stone B., Graves S.S., Fuller D.H., De Rosa S.C., Spies G.A., Mize G.J., Fuller J.T. & Storb R. 2015. Development of a minor histocompatibility antigen vaccine regimen in the canine model of hematopoietic cell transplantation. Transplantation 99(10):2083-2094., Suter et al. 2015Suter S.E., Hamilton M.J., Sullivan E.W. & Venkataraman G.M. 2015. Allogeneic hematopoietic cell transplantation in a dog with acute large granular lymphocytic leukemia. J. Am. Vet. Med. Assoc. 246(9):994-947., Luangphakdy et al. 2016Luangphakdy V., Boehm C., Pan H., Herrick J., Zaveri P. & Muschler G.F. 2016. Assessment of methods for rapid intraoperative concentration and selection of marrow-derived connective tissue progenitors for bone regeneration using the canine femoral multidefect model. Tissue Eng. A 22(1/2):17-30., Lange et al. 2017Lange S., Steder A., Killian D., Knuebel G., Sekora A., Vogel H., Lindner I., Dunkelmann S., Prall F., Escobar H.M., Freund M. & Junghanss C. 2017. Engraftment efficiency after intra-bone marrow versus intravenous transplantation of bone marrow cells in a canine nonmyeloablative dog leukocyte antigen-identical transplantation model. Biol. Blood Marrow Transplant. 23(2):247-254.)