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vol.20 número3Genetic variability of Prochilodus lineatus (Characiformes, Prochilodontidae) in the upper Paraná riverErythrocytes modulate cell cycle progression but not the baseline frequency of sister chromatid exchanges in pig lymphocytes índice de autoresíndice de materiabúsqueda de artículos
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Brazilian Journal of Genetics

versión impresa ISSN 0100-8455versión On-line ISSN 1678-4502


DIAS, Francisca da Luz; ANTUNES, Lusânia M.G.  y  TAKAHASHI, Catarina S.. Effect of taxol on chromosome aberrations induced by gamma radiation or by doxorubicin in Chinese hamster ovary cells. Braz. J. Genet. [online]. 1997, vol.20, n.3, pp.-. ISSN 0100-8455.

Combined therapy with radiation and chemotherapy has being increasingly used in cancer treatment. The effect of combinations of taxol (0.08 mg/ml) with doxorubicin (DXR, 0.5 or 1.0 mg/ml) or gamma radiation (20 or 40 cGy) was examined in two different treatment schedules (pretreatment or simultaneous treatment) using Chinese hamster ovary (CHO) cells treated at the G2 phase of the cell cycle. The results showed that taxol did not have a radiosensitizing effect on the chromosomal aberrations induced by gamma radiation nor did it have a potentiating effect on the chromosomal aberrations induced by DXR in CHO cells treated in the G2 phase of the cell cycle

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