SciELO - Scientific Electronic Library Online

vol.30 número5Partial recovery of erythrocyte glycogen in diabetic rats treated with phenobarbitalMonosodium glutamate (MSG)-obese rats develop glucose intolerance and insulin resistance to peripheral glucose uptake índice de autoresíndice de materiabúsqueda de artículos
Home Pagelista alfabética de revistas  

Brazilian Journal of Medical and Biological Research

versión On-line ISSN 1414-431X


Spreading depression is facilitated in adult rats previously submitted to short episodes of malnutrition during the lactation period. Braz J Med Biol Res [online]. 1997, vol.30, n.5, pp.663-669. ISSN 1414-431X.

Lactating rat dams were submitted to short episodes (1, 2 or 3 weeks) of nutritional restriction by receiving the "regional basic diet" (RBD, with 8% protein) of low-income human populations of Northeast Brazil. Their pups were then studied regarding the developmental effects on body and brain weights. When the rats reached adulthood, cortical susceptibility to the phenomenon of spreading depression (SD) was evaluated by performing electrophysiological recordings on the surface of the cerebral cortex. SD was elicited at 20-min intervals by applying 2% KCl for 1 min to a site on the frontal cortex and its occurrence was monitored at 2 sites in the parietal region by recording the electrocorticogram and the slow potential change of SD. When compared to control rats fed a commercial diet with 23% protein, early malnourished rats showed deficits in body and brain weights (10% to 60% and 3% to 15%, respectively), as well as increases in velocity of SD propagation (10% to 20%). These effects were directly related to the duration of maternal dietary restriction, with pups malnourished for 2 or 3 weeks presenting more intense weight and SD changes than those malnourished for 1 week. The effects of 1-week restrictions on SD were less evident in the pups malnourished during the second week of lactation and were more evident in pups receiving the RBD during the third week. The results indicate that short episodes of early malnutrition during the suckling period can affect body and brain development, as well as the cortical susceptibility to SD during adulthood. The data also suggest that the third week of lactation is the period during which the brain is most sensitive to malnutrition, concerning the effects on SD

Palabras clave : early protein malnutrition; spreading depression; brain growth spurt period.

        · texto en Inglés     · Inglés ( pdf epdf )


Creative Commons License Todo el contenido de esta revista, excepto dónde está identificado, está bajo una Licencia Creative Commons