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Brazilian Journal of Medical and Biological Research

versión impresa ISSN 0100-879Xversión On-line ISSN 1414-431X


BASTOS, A.C.S.C. et al. Role of Tamm-Horsfall protein in the binding and in vivo phagocytosis of type 1 fimbriated Escherichia coli by mouse peritoneal macrophages. Braz J Med Biol Res [online]. 2001, vol.34, n.7, pp.913-917. ISSN 0100-879X.

Tamm-Horsfall glycoprotein (THP) contains manno-oligosaccharides that are recognized by type 1 fimbriae (F1) of Escherichia coli. In the present study, we examined the in vivo phagocytic activity of mouse peritoneal macrophages after treatment of bacteria with THP. At low THP concentrations (12.5 µg/ml and 50 µg/ml) no significant difference was observed in the phagocytosis of E. coli F1+. However, at high THP concentrations (500 µg/ml and 1250 µg/ml) we obtained a reduction of bacterial phagocytosis by mouse peritoneal macrophages.

Palabras clave : Tamm-Horsfall protein; type 1 fimbriated E. coli; phagocytosis.

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