Brazilian Journal of Medical and Biological Research
On-line version ISSN 1414-431X
CARUSO-NEVES, C.; RANGEL, L.B.A.; LARA, L.S. and LOPES, A.G.. Regulation of the renal proximal tubule second sodium pump by angiotensins. Braz J Med Biol Res [online]. 2001, vol.34, n.8, pp. 1079-1084. ISSN 1414-431X. http://dx.doi.org/10.1590/S0100-879X2001000800015.
For several years it was believed that angiotensin II (Ang II) alone mediated the effects of the renin-angiotensin system. However, it has been observed that other peptides of this system, such as angiotensin-(1-7) (Ang-(1-7)), present biological activity. The effect of Ang II and Ang-(1-7) on renal sodium excretion has been associated, at least in part, with modulation of proximal tubule sodium reabsorption. In the present review, we discuss the evidence for the involvement of Na+-ATPase, called the second sodium pump, as a target for the actions of these compounds in the regulation of proximal tubule sodium reabsorption.
Keywords : Na+-ATPase; angiotensin II; angiotensin-(1-7); furosemide; proximal tubule.