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vol.36 issue8Glycosaminoglycans affect the interaction of human plasma kallikrein with plasminogen, factor XII and inhibitorsDistribution of versican and hyaluronan in the mouse uterus during decidualization author indexsubject indexarticles search
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Brazilian Journal of Medical and Biological Research

Print version ISSN 0100-879XOn-line version ISSN 1414-431X


TENORIO, D.M.H.; SANTOS, M.F.  and  ZORN, T.M.T.. Distribution of biglycan and decorin in rat dental tissue. Braz J Med Biol Res [online]. 2003, vol.36, n.8, pp.1061-1065. ISSN 0100-879X.

Biglycan and decorin are small leucine-rich proteoglycans that play several biological and structural roles in different tissues and organs. Several reports have indicated that biglycan participates in odontoblast and ameloblast differentiation and in the calcification process. In the present study we show that the expression of biglycan changes from within the ameloblasts and odontoblasts to the extracellular space according to the stage of animal development. In predentin and in the pulp space, however, biglycan was continually expressed throughout the period of investigation. In contrast, decorin was absent in odontoblasts and in ameloblasts and was exclusively expressed in predentin throughout the period of observation. In young rats, however, decorin was expressed in the extracellular spaces of the pulp, where it was concentrated mainly in the peripheral pulp.

Keywords : Decorin; Biglycan; Odontoblasts; Predentin; Immunohistochemistry.

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