SciELO - Scientific Electronic Library Online

 
vol.38 issue10The prima donna of epigenetics: the regulation of gene expression by DNA methylationRegulation and function of neurogenesis in the adult vertebrate brain author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Journal

Article

Indicators

Related links

Share


Brazilian Journal of Medical and Biological Research

Print version ISSN 0100-879XOn-line version ISSN 1414-431X

Abstract

MELLO-COELHO, V. de  and  HESS, K.L.. A conceptual and practical overview of cDNA microarray technology: implications for basic and clinical sciences. Braz J Med Biol Res [online]. 2005, vol.38, n.10, pp.1543-1552. ISSN 0100-879X.  http://dx.doi.org/10.1590/S0100-879X2005001000011.

cDNA microarray is an innovative technology that facilitates the analysis of the expression of thousands of genes simultaneously. The utilization of this methodology, which is rapidly evolving, requires a combination of expertise from the biological, mathematical and statistical sciences. In this review, we attempt to provide an overview of the principles of cDNA microarray technology, the practical concerns of the analytical processing of the data obtained, the correlation of this methodology with other data analysis methods such as immunohistochemistry in tissue microarrays, and the cDNA microarray application in distinct areas of the basic and clinical sciences.

Keywords : Biotechnology; cDNA microarray; Gene expression; Genomics.

        · text in English     · English ( pdf )

 

Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License