SciELO - Scientific Electronic Library Online

 
vol.43 issue12A clinical gamma camera-based pinhole collimated system for high resolution small animal SPECT imagingIncreased levels of glutamate in the central nervous system are associated with behavioral symptoms in experimental malaria author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Brazilian Journal of Medical and Biological Research

On-line version ISSN 1414-431X

Abstract

GASPAR-SOBRINHO, F.P. et al. Clinical and immunological features of patients with atopy and concomitant HTLV-1 infection. Braz J Med Biol Res [online]. 2010, vol.43, n.12, pp. 1167-1172.  Epub Dec 03, 2010 ISSN 1414-431X.  http://dx.doi.org/10.1590/S0100-879X2010007500138.

Human T-cell lymphotropic virus type 1 (HTLV-1) induces an exacerbated type 1 immune response characterized by high spontaneous IFN-γ and TNF-α production. Allergic rhinitis and asthma are associated with the type 2 immune response, with elevated secretion of IL-4 and IL-5. The aim of this study was to characterize the immune response in atopic HTLV-1 carriers. The cytokine profile of atopic HTLV-1 carriers (N = 10; all females) was compared with that of non-atopic HTLV-1 carriers (N = 14; 9 females and 5 males). Mean patient age of atopic and non-atopic groups was 45 ± 8 and 38 ± 11 years, respectively. All atopic HTLV-1 carriers had rhinitis with or without asthma and a skin prick test positive for Dermatophagoides pteronyssinus antigen 1 (Derp-1). There was no difference in cytokine levels between the two groups in unstimulated peripheral blood mononuclear cell cultures. In cultures stimulated with Derp-1, IFN-γ levels tended to be higher (P = 0.06) and IL-5 levels were higher (P = 0.02) in atopic HTLV-1 patients than in non-atopic subjects. In contrast, IL-10 was lower (P = 0.004) in atopic than in non-atopic HTLV-1-infected subjects. This study shows that HTLV-1 infection with an exaggerated type 1 immune response does not prevent atopy. In this case, the exacerbated type 1 and type 2 immune responses were due to a lack of IL-10 production, a cytokine that plays an important role in down-modulating type 1 and type 2 immune responses and in preventing the development of chronic inflammatory diseases.

Keywords : Asthma; Atopy; Cytokines; HTLV-1; Rhinitis.

        · text in English     · pdf in English