SciELO - Scientific Electronic Library Online

 
vol.44 issue9Central chemoreceptors and neural mechanisms of cardiorespiratory controlPrenatally programmed hypertension: role of maternal diabetes author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Journal

Article

Indicators

Related links

Share


Brazilian Journal of Medical and Biological Research

On-line version ISSN 1414-431X

Abstract

STEFANON, I.; DOS SANTOS, L.  and  BALDO, M.P.. Remodeling in the ischemic heart: the stepwise progression for heart. Braz J Med Biol Res [online]. 2011, vol.44, n.9, pp.890-898.  Epub Aug 05, 2011 ISSN 1414-431X.  http://dx.doi.org/10.1590/S0100-879X2011007500096.

Abstract Coronary artery disease is the leading cause of death in the developed world and in developing countries. Acute mortality from acute myocardial infarction (MI) has decreased in the last decades. However, the incidence of heart failure (HF) in patients with healed infarcted areas is increasing. Therefore, HF prevention is a major challenge to the health system in order to reduce healthcare costs and to provide a better quality of life. Animal models of ischemia and infarction have been essential in providing precise information regarding cardiac remodeling. Several of these changes are maladaptive, and they progressively lead to ventricular dilatation and predispose to the development of arrhythmias, HF and death. These events depend on cell death due to necrosis and apoptosis and on activation of the inflammatory response soon after MI. Systemic and local neurohumoral activation has also been associated with maladaptive cardiac remodeling, predisposing to HF. In this review, we provide a timely description of the cardiovascular alterations that occur after MI at the cellular, neurohumoral and electrical level and discuss the repercussions of these alterations on electrical, mechanical and structural dysfunction of the heart. We also identify several areas where insufficient knowledge limits the adoption of better strategies to prevent HF development in chronically infarcted individuals.

Keywords : Coronary occlusion; Inflammation; Collagen remodeling; Mechanical dysfunction; Heart failure; Rats.

        · text in English     · English ( pdf )

 

Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License