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Brazilian Journal of Medical and Biological Research

On-line version ISSN 1414-431X


GOMES, G.N.  and  GIL, F.Z.. Prenatally programmed hypertension: role of maternal diabetes. Braz J Med Biol Res [online]. 2011, vol.44, n.9, pp.899-904.  Epub Aug 26, 2011 ISSN 1414-431X.

Epidemiological and experimental studies have led to the hypothesis of the fetal origin of adult diseases, suggesting that some adult diseases might be determined before birth by altered fetal development. Maternal diabetes subjects the fetus to an adverse environment that has been demonstrated to result in metabolic, cardiovascular and renal impairment in the offspring. The growing amount of obesity in young females in developed and some developing countries should contribute to increasing the incidence of diabetes among pregnant women. In this review, we discuss how renal and extrarenal mechanisms participate in the genesis of hypertension induced by a diabetic status during fetal development.

Keywords : Hypertension; Maternal diabetes; Renal impairment; Sodium retention.

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