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Brazilian Journal of Medical and Biological Research

On-line version ISSN 1414-431X

Abstract

DELGADO FILHO, V.S.; LOPES, P.F.I.; PODRATZ, P.L.  and  GRACELI, J.B.. Triorganotin as a compound with potential reproductive toxicity in mammals. Braz J Med Biol Res [online]. 2011, vol.44, n.9, pp.958-965.  Epub Aug 26, 2011 ISSN 1414-431X.  http://dx.doi.org/10.1590/S0100-879X2011007500110.

Organotin compounds are typical environmental contaminants and suspected endocrine-disrupting substances, which cause irreversible sexual abnormality in female mollusks, called "imposex". However, little is known about the capability of triorganotin compounds, such as tributyltin and triphenyltin, to cause disorders in the sexual development and reproductive functions of mammals, including humans and rodents. Moreover, these compounds can act as potential competitive inhibitors of aromatase enzyme and other steroidogenic enzymes, affecting the reproductive capacity of male and female mammals. In this review, we discuss the cellular, biochemical, and molecular mechanisms by which triorganotin compounds induce adverse effects in the mammalian reproductive function.

Keywords : Tributyltin; Triphenyltin; Endocrine disruptor; Aromatase; Imposex; Mammalian reproductive organs.

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