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Brazilian Journal of Medical and Biological Research

Print version ISSN 0100-879XOn-line version ISSN 1414-431X

Abstract

CHEN, Jie; WU, Yu; YU, Jiannong  and  SHEN, Jinming. Association between tumor necrosis factor alpha rs1800629 polymorphism and risk of osteoarthritis in a Chinese population. Braz J Med Biol Res [online]. 2018, vol.51, n.8, e7311.  Epub May 28, 2018. ISSN 0100-879X.  https://doi.org/10.1590/1414-431x20187311.

Osteoarthritis (OA) is the most common degenerative disease affecting articular cartilage. Some studies indicate that tumor necrosis factor alpha (TNF-α) gene rs1800629 polymorphism was associated with OA risk among Caucasian populations. To examine the role of this candidate gene in Asian populations, we conducted a hospital-based case-control study involving 257 knee OA patients and 305 controls in a Chinese population. Genotyping was performed using a custom-by-design 48-Plex single nucleotide polymorphism (SNP) Scan™ kit. Our study indicated that the AA genotype of TNF-α rs1800629 polymorphism was associated with increased risk of OA. Subsequently, we conducted a meta-analysis and found that rs1800629 polymorphism increased the risk of OA in the recessive and homozygous models. Stratification analysis of ethnicity also obtained a significant association among Asian populations. In conclusion, TNF-α rs1800629 polymorphism confers susceptibility to OA, especially among Asians. Larger studies with more diverse ethnic populations are needed to confirm these results.

Keywords : TNF-α; Osteoarthritis; Polymorphism; Meta-analysis.

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