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Jornal Brasileiro de Nefrologia
Print version ISSN 0101-2800
BREITSAMETER, Guilherme; FIGUEIREDO, Ana Elizabeth and KOCHHANN, Daiana Saute. Calculation of Kt/V in haemodialysis: a comparison between the formulas. J. Bras. Nefrol. [online]. 2012, vol.34, n.1, pp. 22-26. ISSN 0101-2800. http://dx.doi.org/10.1590/S0101-28002012000100004.
INTRODUCTION: The quality of delivered dialysis can be measured by the Kt/V ratio, which can be calculated in various ways. OBJECTIVE: To compare the Kt/V ratio obtained with the formulas of Lowrie (L) and Daugirdas (D) with the results measured by an Online Clearance Monitor (OCM). Method: Observational, cross-sectional study of 59 patients on hemodialysis (HD). Data were collected in the same dialysis session (predialysis and postdialysis urea) and Kt/V was calculated by the OCM of the Fresenius 4008S machine (Fresenius Medical Care AG, Bad Homburg, Germany). RESULTS: A total of 95 sessions were assessed, with a predominance of males 56% (33), and a sample mean age of 57 + 14 years. Hypertension (42%; n = 25), diabetes (12%; n = 7) and glomerulonephritides (8%; n = 5) were the most frequent causes of chronic kidney disease (CKD). Mean Kt/V values obtained with the L and D formulas and the OCM were 1.31, 1.41 and 1.32, respectively. Comparison between the L and D formulas showed a statistically significant difference (p = 0.008), with a Pearson's correlation of 0.950. The difference between the D formula and the OCM was also significant (p = 0.011 and r = 0.346), probably due to convective loss, estimated by the D formula but not by the OCM and L formula. The difference between the L formula and the OCM was not significant (p = 0.999 and r = 0.577). CONCLUSION: These data suggest that the OCM can be used as a guide to the real-time adjustment of the dialysis dose.
Keywords : Dialysis; Renal Insufficiency, Chronic; Quality Control.