Jornal Brasileiro de Nefrologia
Print version ISSN 0101-2800
VAISBICH, Maria Helena et al. The long-term use of enalapril and hydrochlorothiazide in two novel mutations patients with Dent's disease type 1. J. Bras. Nefrol. [online]. 2012, vol.34, n.1, pp. 78-81. ISSN 0101-2800. http://dx.doi.org/10.1590/S0101-28002012000100013.
Dent's disease type 1 is an X-linked tubular disease caused by mutations in the renal chloride channel CLCN-5, and it is characterized by low molecular weight proteinuria, hypercalciuria, nephrocalcinosis, and renal failure. Several cases have been described in which the only presenting symptoms were asymptomatic proteinuria, and focal segmental or global glomerulosclerosis. The renal failure in these patients may be caused by hypercalciuria and persistent proteinuria. Therefore, angiotensin converse enzyme inhibitor and thiazides could be useful. Our aim is to report the effects of these drugs in two novel mutations patients with Dent's disease type 1. In this report, no significant correlations between dosage of hydrochlorothiazide and calciuria and no significant correlations between proteinuria and dosage of enalapril were detected. This is important since these are polyuric patients and these drugs could be dangerous to their renal function.
Keywords : Enalapril; Proteinuria; Hypercalciuria; Hydrochlorothiazide; Dent Disease.