SELE
|
E Selectin, adhesion molecule |
rs5355C > T |
Cross-sectional study. 40 subjects (median age: 45 years; 50% women) and 30 controls (median age: 36.5 years; 63.3% women). SNP determination by PCR-RFLP |
There was no difference in comparing the right and left media-intima thickness and the right and left cross-sectional areas between the CC, CT and TT from the do SELE SNP rs5355C > T |
Isaac et al., 20144040 Issac MSM, Afif A, Gohar NA, Fayek NA, Zayed B, Sedrak H, et al. Association of E-selectin gene polymorphism and serum PAPP-A with carotid atherosclerosis in end-stage renal disease. Mol Diagn Ther 2014;18:243-52.
|
HMOX1
|
Heme oxigenase 1 |
The allele frequencies of the dinucleotide-guanosinatimidine repetitions length (the S allele represents shorter repetitions (< 27) and the L allele represents longer repetitions (≥ 27). |
Cohort study. 1080 subjects (51.1% men; age: 59 years) and 365 controls (52.1% men; age: 57 years). SNP determination by PCR |
The L/L genotype had higher mortality by CVD and by all causes. |
Chen et al., 20134545 Chen YH, Hung SC, Tarng DC. Length polymorphism in heme oxygenase-1 and cardiovascular events and mortality in hemodialysis patients. Clin J Am Soc Nephrol 2013;8:1756-63.
|
ICAM-1
|
Intercellular –I adhesion molecule |
K469E; TT, TC and CC genotypes |
Cross-sectional study. 1016 Caucasian subjects (656 with CVD: age 62.8 ± 15 59.9% men and 360 without CVD: age: 56.8 ± 14.3, 51.9% men); 824 controls (age: 52.1 ± 14; 55.2% men). SNP determination by PCR + allele-specific. |
Upon stratifying the patients according to CVD clinical characteristics, there was a trend for higher frequencies of the T allele and TT genotype in patients with AMI; Bearing the T allele was an independent risk factor for CVD susceptibility. |
Buraczynska et al., 20122020 Buraczynska M, Zaluska W, Baranowicz-Gaszczyk I, Buraczynska K, Niemczyk E, Ksiazek A. The intercellular adhesion molecule-1 (ICAM-1) gene polymorphism K469E in end-stage renal disease patients with cardiovascular disease. Hum Immunol 2012;73:824-8.
|
IL-6
|
Interleukin-6 |
-634C/G, -174G/C and -572C/G. |
Cross-sectional study 216 subjects with CAD (age: 58.6±10.6 years; 61.1% men). SNP determination by PCR RFLP. |
Positive association of the -634GG and -174CC genotypes and risk of cardiovascular events; There was no association between the 572C/G SNP and the risk of cardiovascular events. |
Song et al., 201588 Song Y, Gu HD, He Y, Wang JW. Role of IL-6 polymorphism on the development of cardiovascular events and coronary artery disease in patients receiving hemodialysis. Genet Mol Res 2015;14:2631-7.
|
IL-6, IL-10 and the tumor necrosis factor
|
Interleucina-6 and 10 and the tumor necrosis factor |
TNF:-308 G/A (rs 1800629); IL-6: -174 G/A (rs 1800795); IL-10: -1082 G/A (rs1800896) |
Cross-sectional study. 169 Caucasian subjects (age: 62 ± 11 years; 62.1% men). SNP determination by PCR. |
Heterozygotes for the IL-10 gene had less cardiovascular events; Patients with the A allele (TNF gene) had higher risk of developing cardiovascular events Having the G allele (IL-6 gene) had a protective effect over cardiovascular events. |
Tosic Dragovic et al., 20161717 Tosic Dragovic J, Popovic J, Djuric P, Jankovic A, Bulatovic A, Barovic M, et al. Relative risk for cardiovascular morbidity in hemodialysis patients regarding gene polymorphism for Il-10, Il-6 and TNF. Can J Physiol Pharmacol. 2016;94:1106-9.
|
NOX
|
NADP oxidase |
C242T |
Cross-sectional study. 289 Chinese subjects: 192 without CVD (Group N; Age: 53.3 ± 12.6; 51.6% men) and 97 with CVD (Group D; age 54.4 ± 11.5 years; 51.4% men). SNP determination by PCR RFLP. |
T+TT genotype frequency was significantly lower in the D Group when compared to the N Group. |
Tang et al., 20102929 Tang FY, Zhu Y, Wang GH, Xie XW. Relation between development of cardiovascular disease and the C242T CYBA polymorphism of the NADPH oxidase in ESRD patients. Dis Markers 2010;29:89-93.
|
RAGE
|
Advanced glycation final products receptor |
-374 T/A |
Case control study 1866 Caucasian subjects (age: 61.6 ± 17.2; 57.0% men) and 1143 healthy subjects (age: 54 ± 19.1; 55.2% men); 63 subjects with ischemic stroke (age: 66.3 ± 14.5 years; 52.1% women). SNP determination by PCR. |
Stroke subjects had lower frequencies of the A allele when compared to those patients without CVD. |
Buraczynska et al., 20152525 Buraczynska M, Zaluska W, Buraczynska K, Markowska-Gosik D, Ksiazek A. Receptor for advanced glycation end products (RAGE) gene polymorphism and cardiovascular disease in end-stage renal disease patients. Hum Immunol 2015;76:843-8.
|
UGT1A1
|
Uridine diphosphato-glucuronosiltransferase |
UGT1A1*28 |
Cohort study. 661 subjects (50.7% men; age: 58 years) and 152 controls (53.9% men; age: 59 years). SNP determination by PCR. |
Subjects with the 7/7 genotype had significantly higher bilirubin levels when compared to those with the 6/6 and 7/6 genotypes; Subjects with the 7/7 genotype had approximately 1/10 of the risk for cardiovascular events and 1/4 of the risk for all-cause mortality when compared to those bearing the allele 6. |
Chen et al., 20113737 Chen YW, Hung SC, Tarng DC. Serum bilirubin links UGT1A1*28 polymorphism and predicts long-term cardiovascular events and mortality in chronic hemodialysis patients. Clin J Am Soc Nephrol 2011;6:567-74.
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