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Archives of Clinical Psychiatry (São Paulo)

versão impressa ISSN 0101-6083

Resumo

JORNADA, Luciano K. et al. Decreased BDNF levels in amygdala and hippocampus after intracerebroventricular administration of ouabain. Rev. psiquiatr. clín. [online]. 2012, vol.39, n.5, pp.157-160. ISSN 0101-6083.  https://doi.org/10.1590/S0101-60832012000500002.

OBJECTIVE: The present study aims to investigate the effects of ouabain intracerebroventricular injection on BDNF levels in the amygdala and hippocampus of Wistar rats. METHODS: Animals received a single intracerebroventricular injection of ouabain (10-3 and 10-2 M) or artificial cerebrospinal fluid and immediately, 1h, 24h, or seven days after injection, BDNF levels were measured in the rat's amygdala and hippocampus by sandwich-ELISA (n = 8 animals per group). RESULTS: When evaluated immediately, 3h, or 24h after injection, ouabain in doses of 10-2 and 10-3 M does not alter BDNF levels in the amygdala and hippocampus. However, when evaluated seven days after injection, ouabain in 10-2 and 10-3 M, showed a significant reduction in BDNF levels in both brain regions evaluated. DISCUSSION: In conclusion, we propose that the ouabain decreased BDNF levels in the hippocampus and amygdala when assessed seven days after administration, supporting the Na/K ATPase hypothesis for bipolar illness.

Palavras-chave : BDNF; mania; Na/K ATPase; ouabain.

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