Le Grange et al. (1992)2020. Le Grange D, Eisler I, Dare C, Russell GFM. Evaluation of family treatments in adolescent anorexia nervosa: a pilot study. Int J Eat Disord. 1992;12(4):347-57. (England) |
To assess the effects of two modalities of family therapy: CFT and SFT for adolescents with AN in outpatient treatment. |
18 |
15.33 (SD = 1.81) |
CFT vs. SFT |
RCT |
9 |
MRAOS, EAT, RSE, SCFI, FACES-III |
Of the 18 participants, 12 (67%) had a good/intermediate outcome, considering both treatments together, and 6 (33%), had a poor outcome. Both treatments showed improvement in terms of weight gain and relief of psychological symptoms, with no differences between groups (p > 0.05). |
Period: Two years after baseline. Result: There were no changes. |
Robin et al. (1994)2929. Robin AL, Siegel PT, Koepke T, Moye AW, Tice S. Family therapy versus individual therapy for adolescent females with anorexia nervosa. J Dev Behav Pediatr. 1994;15(2):111-6. (United States) |
Assess the impact on family relations for BFST vs. EOIT. |
22 |
BFST: 14.7, (SD = 2.7) EOIT: (13.9) SD = 2.1) |
BFST vs. EOIT (Current name: ASF) |
RCT |
48 |
PARQ OFC |
55% of the BFST participants and 46% of the IOTR participants recovered in terms of weight and menstruation (p > 0.05). Descriptive analysis indicates better results from BFST. |
Period: 12 months. Results: 82% of the BFST participants and 50% of the IOTR participants recovered in terms of weight and menstruation (p > 0.05). |
Robin et al. (1999)3030. Robin AL, Siegel PT, Moye AW, Gilroy M, Dennis AB, Sikand A. A controlled comparison of family versus individual therapy for adolescents with anorexia nervosa. J Am Acad Child Adolesc Psychiatry. 1999;38(12):1482-9. (United States) |
To compare the effectiveness of BFST vs. EOIT in the treatment of adolescents with AN. |
37 |
11-20 years |
BFST vs. EOIT (Current name: ASF) |
RCT |
40 |
EAT, EDI, MFPS, BDI YSR, CBCL, PARQ |
52.6% of BFST patients and 41.2% of patients in the EOIT group reached a 50th percentile in terms of weight (p > 0.05). 94% of the BFST group and 64% of the EOIT group were menstruating regularly (p < 0.05). |
Period: 12 months. Results: 66.7% of the BFST group and 68.8% of the EOIT group reached the 50th percentile of weight (p > 0.05). 92.9% of the girls undergoing BFST and 80% of the EOIT group were menstruating regularly (p > 0.05). |
Eisler et al. (2000)1818. Eisler I, Dare C, Hodes M, Russell G, Dodge E, Le Grange D. Family therapy for adolescent anorexia nervosa: the results of a controlled comparison of two family interventions. J Child Psychol Psychiatry. 2000;41(6):727-36. (England) |
To assess and compare the efficacy of two psychological interventions for AN: CFT vs. SFT. |
40 |
15.5 SD = 1.6 |
CFT vs. SFT |
RCT |
15-16 |
SMFQ, RSE, EAT, EDI, MOCI, FACES III, SCFI |
CFT: 5 (26.3%) patients had a good outcome, 4 (21%) intermediate and 10 (52.7%) were poor. SFT: 10 (47.6%) patients had a good outcome, 6 (28.5%) intermediate and 5 (23.8%) were poor. There were no differences between groups (p > 0.05). |
Did not exist. |
Ball & Mitchell (2004)2525. Ball J, Mitchell P. A randomized controlled study of cognitive behavior therapy and behavioral family therapy for anorexia nervosa patients. Eat Disord. 2004;12(4):303-14. (Australia) |
To compare CBT with BFT in the treatment of adolescents with AN. |
25 |
CBT: 18.45 (SD = 2.57) BFT: 17.58 (SD = 3.37) |
CBT vs. BFT |
RCT |
21-25 |
MRS, EDE, ABOS, EDI, BDI, STAI-YI |
69.2% of CBT participants completed treatment vs. 75% undergoing BFT. 77.8% of those who completed CBT and BFT treatment, had a “good” or “intermediate” outcome (p < 0.05). |
Period: 6 months There were no changes. |
Lock et al. (2005)2727. Lock J, Agras WS, Bryson S, Kraemer HC. A comparison of short- and long-term family therapy for adolescent anorexia nervosa. J Am Acad Child Adolesc Psychiatry. 2005;44(7):632-9. (United States) |
To assess the effects of short term (ST) and long term (LT) of FTB in the treatment of adolescents with AN. |
86 |
15.2 (SD = 1.7) |
FBT |
RCT |
ST: 10 LT: 20 |
YSR, CBCL, EDE, K-SADS, YBC-ED, FES |
There were no differences in primary outcomes (BMI and EDE) in the ST and LT interventions (p > 0.05). The indicators of internalizing behavioral problems (CBCL) and the subscale for eating behavior (EDE) were lower in the participants undergoing LT intervention. |
Did not exist. |
Gowers et al. (2007)2828. Gowers SG, Clark A, Roberts C, Griffiths A, Edwards V, Bryan C, et al. Clinical effectiveness of treatments for anorexia nervosa in adolescents: randomised controlled trial. Br J Psychiatry. 2007;191:427-35. (England) |
To assess the effectiveness of three treatment modalities for AN available in the British healthcare system: CAMHS vs. hospitalization in psychiatric ward vs. outpatient specialty care. |
167 |
12-18 years |
CBT and FBT |
RCT |
20-24 |
EDI, MRAOS, HoNOSCA, FAD, MFQ |
CAMHS: 10 (18.2%) had a good results, 31 (56%) intermediate and 13 (24%) were poor. Specialized outpatient clinic: 8 (15%) had a good outcome, 22 (40%) intermediate and 24 (44%) were poor. Inpatient ward: 12 (21%) had a good results, 18 (32%) intermediate and 26 (46%) were poor. |
Period: 2 years after baseline. Results: CAMHS 20 (36%) had a good outcome, 20 (36%) intermediate and 14 (26%) were poor. Specialized outpatient clinic: 13 (24%) had a good outcome, 28 (51%) intermediate and 12 (22%) were poor. Inpatient ward: 19 (33%) good, 17 (30%) intermediate and 17 (30%) were poor. |
Paulson-Karlsson et al. (2009)1212. Paulson-Karlsson G, Engström I, Nevonen L. A pilot study of a family-based treatment for adolescent anorexia nervosa: 18- and 36-month follow-ups. Eat Disord. 2009;17(1):72-88. (Sweden) |
To assess the effects of FTS + CFT for adolescents with AN undergoing outpatient treatment. |
32 |
15.4 (SD = 1.4) |
SFT + CFT |
Open Trial |
20-25 |
RAB, EDI, YSR, FSC |
No results were reported at the end of treatment. |
Period: 36 months. Results: 25 (78%) of the participants achieved complete remission, with reduction of eating symptoms, internalizing problems and improvement of family situation. No results were reported in terms of good, intermediate or poor outcomes, nor the results at the end of treatment. |
Lock et al. (2010)2626. Lock J, Le Grange D, Agras WS, Moye A, Bryson SW, Jo B. Randomized clinical trial comparing family-based treatment with adolescent-focused individual therapy for adolescents with anorexia nervosa. Arch Gen Psychiatry. 2010;67(10):1025-32. (United States) |
To compare the impact of FBT vs AFT (former EOIT) on complete remission in the treatment of adolescents with AN. |
121 |
14.4 (DP = 1.6) |
FBT vs. AFT |
RCT |
24 |
EDE, K-SADS |
Complete remission in 22.6% undergoing AFT and 41.8% undergoing FBT, (p > 0.05). |
Period: 12 months. Results: complete remission in 23.2% undergoing AFT and 49.3% undergoing FBT (p < 0.05). |
Turkiewicz et al. (2010)2222. Turkiewicz G, Pinzon V, Lock J, Fleitlich-Bilyk B. Feasibility, acceptability, and effectiveness of family-based treatment for adolescent anorexia nervosa: an observational study conducted in Brazil. Rev Bras Psiquiatr. 2010;32(2):169-72. (Brazil) |
To assess the viability, acceptance and efficacy of FBT for AN in adolescents in Brazil. |
9 |
14.64 (DP = 1.63) |
FBT |
Open Trial |
10-12 |
EDE-Q CGAS |
7 (78%) completed the treatment. Six (86%) re-established the target weight, 4 (44%) returned to menstruating regularly. There was no statistically significant reduction in the EDE-Q or CGAS scores. |
Period: 6 months. Results: 7 (100%) were assessed. They all regained their weight and returned to menstruating regularly. There was improvement in CGAS (p < 0.05), but not in the EDE-Q. |
Dalle-Grave et al. (2013)2323. Dalle Grave R, Calugi S, Doll HA, Fairburn CG. Enhanced cognitive behaviour therapy for adolescents with anorexia nervosa: an alternative to family therapy? Behav Res Ther. 2013;51(1):R9-R12. (Italy) |
To assess the effects of the CBT-e intervention in adolescents with AN and to determine if this type of intervention can be an alternative to FBT. |
46 |
15.5 (SD = 1.3) |
CBT-e |
Open Trial |
44 |
EDE-q GSI |
29 (63%) completed treatment, 9 (32%) reestablished 95% of ideal weight and 28 of those who completed treatment (96.6%) reduced symptoms of eating disorders and other psychiatric disorders compared to the baseline of the treatment. |
Period: 12 months. Results: 29 (63%) were assessed at follow-up. Of these, 13 (44.8%) reestablished 95% of the ideal weight. Psychiatric symptoms remained stable. |
Agras et al. (2014)2424. Agras WS, Lock J, Brandt H, Bryson SW, Dodge E, Halmi KA, et al. Comparison of 2 family therapies for adolescent anorexia nervosa: a randomized parallel trial. JAMA Psychiatry. 2014;71(11):1279-86. (United States) |
vs
|
158 |
15.3 (SD = 1.8) |
FBT vs. SyFT |
RCT |
16 |
EDE, BDI, RSES, QLES (short form), SAI, CYBOCS YBCEDS |
All participants completed both treatment modalities. Remission rate of 33.1% for FBT and 25% for SyFT (p > 0.05) in all endpoints, except for the self-esteem scale, in favor of SyFT. |
Period: 12 months. Results: 114 (72%) were assessed. Remission of 40.7% for FBT and 39.0% for SyFT (p > 0.05). Faster weight gain in the FBT group, and fewer days of hospitalization, which makes intervention less costly. |
Timko et al. (2015)99. Timko CA, Zucker NL, Herbert JD, Rodriguez D, Merwin RM. An open trial of Acceptance-based Separated Family Treatment (ASFT) for adolescents with anorexia nervosa. Behav Res Ther. 2015;69:63-74. (United States) |
To assess the feasibility, acceptability and effectiveness of ASFT. |
47 |
14.02 (SD = 1.58) |
ASFT |
Open Trial |
20 |
CEQ, EDE, EDEq, ABOS, famQ, DERS, AFQ-Y and AAQ-2 |
of the participants who started treatment, 49% had complete remission and 29.8% had partial remission. The proportion of patients who completed treatment with total remission was 67.7% and, with partial remission, 32.3%. |
Did not exist. |
Accurso et al. (2015)3131. Accurso EC, Fitzsimmons-Craft EE, Ciao AC, Le Grange D. From efficacy to effectiveness: comparing outcomes for youth with anorexia nervosa treated in research trials versus clinical care. Behav Res Ther. 2015;65:36-41. (United States) |
To compare FBT-based intervention results achieved in a study with a RCT design, of those obtained in a traditional clinical setting (SCC) |
84 |
14.5 (SD = 2.2) |
FBT |
Mixt (Open Trial + RCT) |
18 |
EDE-12.0, KSADS, BDI |
57% of the total participants had reestablished their weight: RCT (62.5%) and SCC (53.8%). There were no differences between groups (p > 0.05). Patients with BMI < 81% of expected had better RCT results (p < 0.05). |
Did not exist. |