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Revista de Psiquiatria do Rio Grande do Sul

Print version ISSN 0101-8108

Abstract

SHORTER, Edward. Looking backwards: a possible new pathway for drug discovery in psychopharmacology. Rev. psiquiatr. Rio Gd. Sul [online]. 2004, vol.26, n.2, pp.196-203. ISSN 0101-8108.  http://dx.doi.org/10.1590/S0101-81082004000200009.

The history of psychopharmacology is littered with type II errors - the rejection of effective compounds in the specious belief that they were inefficacious because they had failed to beat placebo in a controlled trial. Revisiting some of these drugs to establish their receptor profile, and then determining what patentable compounds now on the shelf match that profile, might represent a possible future pathway to drug discovery. This article looks at the special circumstances in which numerous potentially effective drugs were withdrawn in the United States.

Keywords : Psychopharmacology; drug discovery; receptors.

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