SciELO - Scientific Electronic Library Online

vol.32 número2Fatores associados ao uso de psicofármacos em idosos asilados índice de autoresíndice de assuntospesquisa de artigos
Home Pagelista alfabética de periódicos  

Serviços Personalizados




Links relacionados


Revista de Psiquiatria do Rio Grande do Sul

versão impressa ISSN 0101-8108


OLIVEIRA, José Menna et al. Lithium and methylphenidate: opposite effects on perirenal brown fat. Rev. psiquiatr. Rio Gd. Sul [online]. 2010, vol.32, n.2, pp.35-37. ISSN 0101-8108.

OBJECTIVE: To evaluate the effects of the administration of lithium to adult rats on brown (perirenal) and white (inguinal) adipose tissues and to assess whether methylphenidate modulates lithium effects. METHODS: Twenty-five adult male Wistar rats were fed with either regular or lithium-containing chow for 30 days. Between days 15 to 30 of treatment, animals received daily intraperitoneal administrations of either methylphenidate or saline. RESULTS: Lithium significantly reduced perirenal fat, and this effect was minimized by the administration of methylphenidate. There were no significant differences between the groups in terms of the effects of lithium on inguinal fat. CONCLUSION: Our findings suggest that different effects on white and brown tissue distribution may be involved in lithium-induced weight gain.

Palavras-chave : Lithium; methylphenidate; weight gain; obesity.

        · resumo em Português     · texto em Inglês     · Inglês ( pdf )


Creative Commons License Todo o conteúdo deste periódico, exceto onde está identificado, está licenciado sob uma Licença Creative Commons